3, 5-disubstituted pyridine and 3, 5-disubstituted pyridazine derivatives and pharmaceutical use of same

A carboxylic acid compound of formula (1)

• or a pharmacologically acceptable salt thereof,
• wherein R1 is
• where X1a is —C(R1a)2— where plural R1a are the same or different and each R1a is a hydrogen atom, a halogen atom, C1-C2 perfluoroalkyl, C1-C2 perfluoroalkoxy or C1-C6 alkyl, or plural R1a are bonded to form 1,1-C3-C6 cycloalkylene or —NR1b— where R1b is a hydrogen atom or C1-C2 perfluoroalkyl, X1b and X1c are the same or different and each of X1b and X1c is —O— or —CH2— provided X1b and X1c are not simultaneously —O—, R1c is a hydrogen atom, a halogen atom, C1-C2 perfluoroalkyl, C1-C2 perfluoroalkoxy, C1-C6 alkyl or C1-C2 perfluoroalkylthio, R1d is a hydrogen atom, a halogen atom or C1-C6 alkyl, and R1e is a hydrogen atom, C1-C2 perfluoroalkyl or C1-C2 perfluoroalkoxy,
• X is —N═ or —CH═,
• ring A is
• where X2a is —N═ or —CR2a═ where R2a is a hydrogen atom, a halogen atom, C1-C6 alkyl or C1-C6 alkoxy, R2b is a hydrogen atom, a halogen atom, C1-C6 alkyl or C1-C6 alkoxy, R2c is a hydrogen atom or C1-C6 alkyl, X2b is —O—, —NR2d— where R2d is a hydrogen atom or C1-C2 perfluoroalkyl or —CHR2e— where R2e is a hydrogen atom or C1-C6 alkyl, X2c is —(CH2)n′— where n′ is 0 or 1 or —O—, and
• L is —(CHR3a)n— where n is 0, 1, 2 or 3, plural R3a are the same or different and each R3a is a hydrogen atom or a C1-C6 alkyl, —(CH2)m—O—(CH2)m′— where m and m′ are the same or different and each of m and m′ is 0, 1 or 2, C2-C3 alkenylene,
• where R3b and R3c are the same or different and each of R3b and R3c is a hydrogen atom or C1-C6 alkyl, R3d is a hydrogen atom, C1-C6 alkoxy, C1-C6 alkyl or C1-C2 perfluoroalkyl, R3e is a hydrogen atom, C1-C6 alkoxy, C1-C6 alkyl or C1-C2 perfluoroalkyl.