Biomimetic chemocatalytic cascades of degradable polymers

A method of simultaneously modifying degradation rates of at least two compounds comprising a first compound having a first unmodified degradation rate constant k1 and a second compound having a second unmodified degradation rate k2, the method comprising:

• combining a first composition comprising the first compound with a second composition comprising the second compound;
• degrading the first compound and forming a first degradation product;
• and
• degrading the second compound and forming a second degradation product,
• wherein the second degradation product modifies the first unmodified degradation rate constant k1 of the first compound to a first modified degradation rate k1′ and the first degradation product modifies the second unmodified degradation rate k2 of the second compound to a second modified degradation rate k2′,
• wherein either a first negative feedback loop is formed when is less than k1 or a first positive feedback loop is formed when is greater than k1, and
• wherein either a second negative feedback loop is formed when k2′ is less than k2 or a second positive feedback loop is formed when k2′ is greater than k2.