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US 11,957,824 B2Granted
Hemofilter for in vivo blood filtration
AssigneesThe Regents of the University of California, Vanderbilt University
InventorsShuvo Roy, William Fissell, Nathan Wright, Mark Goodin, Steven G. Goebel, Amanda Buck, Joey Groszek
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Abstract
Hemofilters for in vivo filtration of blood are disclosed. The hemofilters disclosed herein provide an optimal flow of blood through the filtration channels while maintaining a pressure gradient across the filtration channel walls to enhance filtration and minimize turbulence and stagnation of blood in the hemofilter.
Claims20
A method for filtering blood in an individual in need thereof, the method comprising:
- connecting a hemofilter to a vascular circulatory system of the individual, the hemofilter comprising:
- an extended inlet manifold;
- a plurality of filtration channels;
- and
- an extended outlet manifold,
- the extended inlet manifold comprising:
- a first region comprising:
- a circular inlet configured for connection to a blood vessel of an individual;
- and a transition section in which lumen of the extended inlet manifold transitions from having a circular cross-section to having a rectangular cross-section;
- and
- a second region comprising a U-shaped turn and followed by a linear tapered section, the linear tapered section comprising a plurality of openings in fluid communication with the plurality of filtration channels,
- wherein the plurality of filtration channels are arranged in a spaced-apart stacked configuration and are in fluid communication with a plurality of openings in a first region of the extended outlet manifold,
- wherein the first region of the extended outlet manifold is parallel to the linear tapered section of the extended inlet manifold and is reverse-tapered with reference to the linear tapered section of the extended inlet manifold and wherein the extended outlet manifold comprises a second region comprising:
- a transition section in which lumen of the extended outlet manifold transitions from having a rectangular cross-section to having a circular cross-section;
- and
- a circular outlet defined by the circular cross-section of the extended outlet manifold, and
- wherein the hemofilter is configured for entry of blood through the circular inlet and for transporting the blood through the transition section of the extended inlet manifold to the tapered linear section, into the plurality of filtration channels to the first region of the extended outlet manifold, into the transition section of the extended outlet manifold, and exit via the circular outlet.
14 more elements
A method for filtering blood in an individual in need thereof, the method comprising:
- connecting a hemofilter to a vascular circulatory system of the individual, the hemofilter comprising:
- an extended inlet conduit;
- a single serpentine filtration channel;
- and an outlet conduit;
- the extended inlet conduit comprising:
- a first region comprising:
- an inlet having a circular cross section shape configured for connection to a blood vessel of an individual;
- and
- a transition region in which lumen enclosed by the first region transitions from the circular cross section shape into a rectangular cross section shape;
- a second region comprising a rectangular cross section and a curved region connected to the single serpentine filtration channel;
- the serpentine filtration channel comprising:
- a plurality of filtration sections arranged in a spaced-apart stacked configuration wherein the plurality of filtration sections are connected via turnaround sections;
- and
- the outlet conduit comprising:
- first region having a rectangular cross-section;
- and
- a second region that transitions from rectangular to a circular cross section and terminates in a circular outlet configured for connection to a blood vessel of the individual.
14 more elements
The method of claimf 9, wherein the plurality of filtration sections comprises 2-50 filtration sections, each disposed between two turnaround sections, wherein each of the plurality of filtration sections has a length of 10 mm-200 mm, a width of 5 mm-100 mm, a height of 0.5 mm-2.5 mm.
A method for filtering blood in an individual in need thereof, the method comprising:
- connecting a hemofilter to a vascular circulatory system of the individual, the hemofilter comprising:
- an extended inlet conduit;
- a single serpentine filtration channel;
- and an outlet conduit;
- the extended inlet conduit comprising:
- an inlet;
- a first transition region;
- a first turnaround section;
- a second transition region;
- a second turnaround section;
- wherein in the first transition region the inlet transitions from a circular cross section, configured for connection to a blood vessel of an individual, into a rectangular cross section,
- wherein the rectangular cross section at an end of the first transition region matches a rectangular cross section of the first turnaround section,
- wherein in the second transition region the first turnaround section expands in width such that a rectangular cross section at an end of the second transition region matches a rectangular cross section of the second turnaround section,
- wherein the rectangular cross section of the second turnaround section matches that of the single serpentine filtration channel;
- the single serpentine filtration channel comprising:
- a plurality of filtration sections arranged in a spaced-apart stacked configuration wherein the filtration sections are connected via turnaround sections;
- and
- the outlet conduit comprising:
- first region having a rectangular cross-section;
- and
- a second region that transitions from the rectangular cross section to a circular cross section and terminates in a circular outlet configured for connection to a blood vessel of an individual.
18 more elements
Dependencies are inferred from the claim text.