Nanoparticles
AssigneeSintef Tto AS
InventorsRuth Schmid, Peter Molesworth, Yrr Mørch, Einar Sulheim, Heidi Johnsen
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Abstract
The present invention provides a nanoparticle comprising a poly(alkyl cyanoacrylate) homopolymer, or copolymer, at least one active agent and an anionic and radical inhibitor, wherein the anionic and radical inhibitor is a compound having the following formula: wherein R1 is H; and R3, R4, R5, R6 and R7 are independently selected from the group consisting of —H, —OH, C1-C6 alkoxide, C1-C6 alkyl, halides, carboxylic acid, ketone or aldehyde; wherein the anionic and radical inhibitor is present in an amount of 0.001 to 15 wt %, as well as a process suitable for manufacture of the nanoparticle.
Claims17
A nanoparticle comprising a poly(alkyl cyanoacrylate) homopolymer, or copolymer, at least one active agent and an anionic and radical inhibitor, wherein
- the anionic and radical inhibitor is a compound having the following formula:
- wherein
- R1 is H;
- and
- R3, R4, R5, R6 and R7 are independently selected from the group consisting of —H, —OH, C1-C6 alkoxide, C1-C6 alkyl, halides, carboxylic acid, ketone and aldehyde;
- wherein the anionic and radical inhibitor is present in an amount of 0.001 to 15 wt %, based on the weight of the nanoparticle.
A process for the preparation of nanoparticles of a poly(alkyl cyanoacrylate) homopolymer or copolymer, comprising, in a single step, the anionic polymerisation of an oil-in-water miniemulsion, wherein said miniemulsion comprises
- (i) at least one alkyl cyanoacrylate monomer;
- (ii) at least one surfactant;
- (iii) one or more active agents;
- (iv) optionally an anionic polymerisation initiator;
- and
- (v) an anionic and radical inhibitor, wherein the anionic and radical inhibitor is a compound having the following formula:
- wherein
- R1 is H;
- and
- R3, R4, R5, R6 and R7 are independently selected from the group consisting of —H, —OH, C1-C6 alkoxide, C1-C6 alkyl, halides, carboxylic acid, ketone and aldehyde.
Dependencies are inferred from the claim text.