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US 11,957,788 B2Granted
Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
AssigneeExicure Operating Company
InventorsAleksandar Filip Radovic-Moreno, Richard Kang, Subbarao Nallagatla, Christopher C. Mader, Sergei Gryaznov
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Abstract
Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
Claims20
A nanostructure, comprising:
- a liposomal core having a lipid bilayer and an oligonucleotide shell oriented radially outwards positioned on the exterior of the liposomal core,
- wherein an antigen is encapsulated within the liposomal core,
- wherein the oligonucleotide shell comprises at least one CpG-motif containing oligonucleotide, and
- wherein the CpG-motif containing oligonucleotide is indirectly linked to the liposomal core through a lipid anchor.
1 more element
Dependencies are inferred from the claim text.