Ophthalmic drug sustained release formulation and uses thereof
OwnerDeepank Utkhede, Catherine Jones +1inventors
InventorsDeepank Utkhede, Catherine Jones, David J. Wiseman
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Abstract
A solid matrix sustained release ophthalmic formulation for topical delivery of a solid ophthalmic drug to the eye, medical devices, drug cores, drug inserts and drug delivery systems comprising the formulation, methods of manufacturing the formulation, medical devices and their methods thereof for delivering the ophthalmic drug for a treatment period provided herein. The formulation disclosed herein is an admixture of an ophthalmic drug, and a combination of a hydrophobic polymer, a hydrophilic polymer and a surfactant, wherein the drug is eluted daily over an extended period of time at therapeutic dose of drug.
Claims20
A drug insert for topical delivery of nepafenac, comprising
- a solid matrix, comprising about 30 to about 15% (w/w) of polycaprolactone, about 5 to about 15% (w/w) of polyethylene glycol (PEG) polymers, about 1 to about 15% w/w of tyloxapol and about 60 to about 70% (w/w) of nepafenac.
A drug insert for topical delivery of nepafenac, comprising about 20% (w/w) of polycaprolactone, about 10% (w/w) of polyethylene glycol (PEG) polymers, about 4% w/w of tyloxapol and about 66% (w/w) of nepafenac.
Dependencies are inferred from the claim text.