Immune tolerant and non-immune tolerant elastin-like recombinant peptides and methods of use
AssigneeUniversity of Utah Research Foundation
InventorsMingnan Chen, Hyung Jin Cho, Peng Wang, Shuyun Dong, Peng Zhao
Life of this patent
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Abstract
Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats; and, non-immunogenic bioconjugates comprising recombinant polypeptides comprising one or more homologous amino acid repeats and one or more therapeutic agents. Also, disclosed herein are pharmaceutical compositions including the recombinant polypeptides; and methods of administering the recombinant polypeptides to patients for the treatment of cancer or infections.
Claims5
A recombinant polypeptide comprising an homologous amino acid repeat sequence, wherein the homologous amino acid repeat sequence is Gly-Val-Leu-Pro-Gly-Val-Gly (SEQ ID NO:
- 1:
- iTEPA), wherein the homologous amino acid repeat sequence is reiterated linearly.
A recombinant polypeptide comprising
- (SEQ ID NO:
- 23)
- Gly-(Gly-Val-Leu-Pro-Gly-Val-Gly)28-Gly-Gly;
- (SEQ ID NO:
- 24)
- Gly-(Gly-Ala-Gly-Val-Pro-Gly)70-Gly-Gly;
- (SEQ ID NO:
- 25)
- Gly-(Val-Pro-Gly-Phe-Gly-Ala-Gly-Ala-Gly)21-Gly-
- Gly;
- or
- (SEQ ID NO:
- 26)
- Gly-(Val-Pro-Gly-Leu-Gly-Ala-Gly-Ala-Gly)96-Gly-
- Gly.
Dependencies are inferred from the claim text.