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US 11,957,759 B1Granted
Rapidly accelerated fibrosarcoma (RAF) degrading compounds and associated methods of use
AssigneeArvinas Operations, Inc.
InventorKeith R. Hornberger
Life of this patent
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Abstract
Provided herein are bifunctional compounds having the chemical structure I: PTM-L-CLM (I): or pharmaceutically acceptable salts thereof, which find utility as modulators of Rapidly Accelerated Fibrosarcoma (Raf, such as c-Raf, A-Raf, and/or B-RAF) and are useful in the treatment of a variety of Raf mediated conditions or diseases, such as cancer, specifically lung cancer, skin cancer, or colorectal cancer.
Claims6
A compound represented by the structural formula:
A compound represented by the structural formula:
- or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a compound represented by the structural formula:
- or a pharmaceutically acceptable salt thereof;
- and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.