Pharmaceutical composition of docetaxel conjugate and preparation method

A pharmaceutical composition, including:

• (1) a lyophilized powder of a docetaxel conjugate composition comprising (i) a docetaxel conjugate, and (ii) one or more pharmaceutically acceptable carriers which have no surfactant, and the pH value of the docetaxel conjugate composition ranges from 4.5-5.5 before lyophilization;
• and (2) a reconstitution solvent which contains one or more surfactants at 0.1 to 15 parts by weight, based on 1 part by weight of the docetaxel conjugate, wherein components (1) and (2) are separate in different chambers, and the docetaxel conjugate has the structure:
• or a pharmaceutically acceptable salt thereof, or an ester thereof having the structure:
• wherein, R1 is selected from phenyl or one or more halogen-substituted phenyl, halogen is selected from fluorine, chlorine, bromine, or iodine, n is a natural number of 2 to 5, and is selected from 2, 3, 4, or 5.