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US 11,957,757 B2Granted
Method for preparing stabilized metal ion ligand nanocomplex and compositions thereof
AssigneeAuburn University
InventorsFeng Li, Wu Chen, Pengyu Chen
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Abstract
The present disclosure provides method of making a nanoparticle complex wherein the nanoparticle complex comprises a ligand and a metal cation. The disclosure also provides nanoparticle complexes, methods of treating a disease in a patient utilizing the nanoparticle complexes, methods of identifying a disease in a patient utilizing the nanoparticle complexes, and kits involving the nanoparticle complexes.
Claims17
A method of making a nanoparticle complex, said method comprising the steps of:
- providing a first composition, wherein the first composition comprises at least one ligand and at least one stabilizer;
- providing a second composition, wherein the second composition comprises a salt of the formula MnXy and at least one stabilizer,
- wherein M is a metal cation and X is counterion, and
- wherein n is an integer from 1 to 3 and y is an integer from 1 to 5;
- and
- combining the first composition and the second composition to obtain the nanoparticle complex, wherein the nanoparticle complex comprises the ligand and M,
- wherein the method further comprises a step of providing a third composition comprising one or more stabilizers, and wherein the combining of the first composition and the second composition is performed prior to combination with the third composition.
4 more elements
Dependencies are inferred from the claim text.