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US 11,957,753 B2Granted
Pharmaceutical formulations containing corticosteroids for topical administration
AssigneeBausch Health Ireland Limited
InventorsArturo Angel, Gordon Dow
Life of this patent
Estimating the term…
Abstract
Pharmaceutical compositions for topical application to skin are provided. In some embodiments, the pharmaceutical compositions comprise a corticosteroid and further comprise a liquid oil component comprising one or more dicarboxylic acid esters and/or monocarboxylic acid esters.
Claims23
A pharmaceutical composition for topical application to the skin of an individual comprising:
- a liquid oil component comprising a dicarboxylic acid ester or a monocarboxylic acid ester, and a mineral oil or a light mineral oil;
- a corticosteroid at a concentration of 0.03% or less, wherein the corticosteroid is selected from the group consisting of halobetasol propionate, clobetasol, betamethasone dipropionate, diflorasone diacetate, desoximetasone, mometasone furoate, betamethasone valerate, halcinonide, fluocinonide, and amcinonide, and wherein at least 25% of the corticosteroid is solubilized in the liquid oil component at a temperature of 22° C.±2° C.;
- and
- an aqueous component comprising water;
- wherein the pharmaceutical composition does not include white petrolatum;
- and
- wherein the pharmaceutical composition is formulated as a lotion or a cream.
4 more elements
A pharmaceutical composition for topical application to the skin of an individual comprising:
- a liquid oil component comprising a dicarboxylic acid ester or a monocarboxylic acid ester, and a mineral oil or a light mineral oil;
- a corticosteroid at a concentration of 0.01% or less, wherein the corticosteroid is selected from the group consisting of halobetasol propionate, clobetasol, betamethasone dipropionate, diflorasone diacetate, desoximetasone, mometasone furoate, betamethasone valerate, halcinonide, fluocinonide, or amcinonide, and wherein at least 25% of the corticosteroid is solubilized in the liquid oil component at a temperature of 22° C.±2° C.;
- and
- an aqueous component comprising water;
- wherein the pharmaceutical composition does not include white petrolatum;
- and
- wherein the pharmaceutical composition is formulated as a lotion or a cream.
4 more elements
Dependencies are inferred from the claim text.