Triple vaccine protects against bacterial and fungal pathogens via trained immunity
AssigneeUniversity of Southern California
InventorsBrad Spellberg, Travis Nielsen, Brian Luna, Jun Yan
Life of this patent
Estimating the term…
Abstract
An optimized protein-free tripartite vaccine that protects against lethal blood and lung infections caused by a variety of nosocomial pathogens across taxonomic kingdoms, including Gram-positive bacteria, Gram-negative bacteria, and fungi.
Claims15
A method of enhancing innate immunity against an infection caused by a bacterial pathogen or a fungal pathogen in a mammalian subject in need thereof, the method comprising administering to the subject an effective amount of a combination
- immunostimulatory composition comprising an effective amount of each of monophosphoryl lipid A (MPL), mannan, and aluminum hydroxide, with the proviso that the composition does not comprise whole glucan particles (WGP) and an antigen that is effective to induce an immune response against the bacterial pathogen or the fungal pathogen.
A method of enhancing innate immunity against an infection caused by a bacterial pathogen or a fungal pathogen in a mammalian subject in need thereof, the method comprising administering to the subject an effective amount of a combination immunostimulatory composition consisting essentially of an effective amount of each of monophosphoryl lipid A (MPL), mannan, and aluminum hydroxide, with the proviso that the composition does not comprise whole glucan particles (WGP) and an antigen that is effective to induce an immune response against the bacterial pathogen or the fungal pathogen.
Dependencies are inferred from the claim text.