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US 11,957,748 B2Granted
Vaccine to pathogenic immune activation cells during infections
Assignee21 C Bio
InventorDaniel Zagury
Life of this patent
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Abstract
A method for preventing an infectious disease in a subject in need thereof. In particular the method includes the administration of a combination, pharmaceutical combination, medicament or kit-of-parts including a first part including a CD8 vaccine specific for at least one infectious disease-related antigen, optionally a second part including an interferon alpha blocking agent, and a third part including a type III interferon and/or an agent stimulating the production of type III interferon.
Claims19
A method for preventing acquired immune deficiency syndrome (AIDS) in a subject in need thereof, comprising administering to the subject:
- 1) A CD8 vaccine specific for at least one human immunodeficiency virus (HIV) antigen,
- 2) optionally interferon-alpha blocking agent, and
- 3) A type III interferon and/or an agent stimulating the production of type III interferon, wherein the type III interferon comprises at least one IFN-λ selected from the group of IFN-λ1, IFN-λ2 IFN-λ3 and IFN-λ4, and wherein the agent stimulating the production of type III interferon comprises at least one TLR ligand, RIG-I ligand, and/or MDA5 ligand.
Dependencies are inferred from the claim text.