Methods and compositions for treating autoimmune and inflammatory conditions
AssigneeBaylor Research Institute
InventorsSangKon Oh, Sandra Zurawski, Hyemee Joo, Gerard Zurawski
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Abstract
Described herein are compositions and methods for inhibiting an inflammatory or autoimmune response and for inducing immune tolerance in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antigen presenting cell (APC)-targeted antibody operatively linked to IL-10 or a fragment thereof. The compositions and methods described herein are useful for treating inflammatory and autoimmune disorders.
Claims20
A method for preventing or treating graft versus host disease (GVHD) in a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of an anti-DC-ASGPR antibody or antigen binding fragment thereof, wherein the pharmaceutical composition does not comprise an antigen associated with an autoimmune disease or inflammatory condition, and wherein the anti-DC-ASGPR antibody or antigen binding fragment thereof is not operably linked to an active ingredient.
A method for preventing or treating graft versus host disease (GVHD) in a subject in need thereof comprising administering to the subject a pharmaceutical composition comprising a therapeutically effective amount of an anti-DC-ASGPR antibody or antigen binding fragment thereof, wherein the pharmaceutical composition does not comprise an antigen associated with an autoimmune disease or inflammatory condition, and wherein the anti-DC-ASGPR antibody or antigen binding fragment thereof is not operably linked to a toxic agent or cytokine.
Dependencies are inferred from the claim text.