Composition controlling pharmacokinetics in the body

A method of reducing clearance function of endothelial cells of liver sinusoidal endothelial cells and/or kidney vascular endothelial cells in a body in need thereof, the method comprising:

• administering to the body an effective amount of a polyvalent cation in a free form to sufficiently cover inner vascular surface of liver sinusoidal endothelial cells and/or kidney vascular endothelial cells with the polyvalent cation, thereby reducing the clearance function of a drug;
• and
• administering to the body the drug encapsulated in a carrier, wherein the carrier is at least one selected from the group consisting of a virus, a liposome, a lipid complex, an ion complex, and a micelle, wherein when the carrier comprises a polyvalent cation, the poly valent cation in the carrier is different from the polyvalent cation in a free form,
• wherein:
• (i) the polyvalent cation is administered prior to the drug administration:
• (ii) the polyvalent cation is administered simultaneously with the drug administration:
• or
• (iii) the polyvalent cation is administered after the drug administration, provided that the administration is performed while the drug remains in blood.