Compositions and methods of use thereof
AssigneeSynedgen, Inc.
InventorsShenda M. Baker, William P. Wiesmann, Stacy Marie Townsend
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Abstract
Described herein are methods for treating or preventing a disease or disorder of the pulmonary system (e.g., cystic fibrosis), respiratory or digestive system in a subject, the methods comprising administering compounds or compositions comprising water soluble polyglucosamine and derivatized polyglucosamine.
Claims19
A method for treating or preventing Acute Respiratory Distress Syndrome (ARDS) in a subject, the method comprising administering to the subject by inhalation an effective amount of a composition comprising a neutral osmol agent and a poly (acetyl, arginyl) glucosamine (PAAG) comprising the following formula (I):
- wherein:
- n is an integer between 20 and 6000;
- and
- each R1 is independently selected for each occurrence from hydrogen, acetyl,
- wherein at least 25% of R1 substituents are H, at least 1% of R1 substituents are acetyl, and at least 2% of R1 substituents are
- wherein the osmolality of the composition is between 150-550 mOsmol/kg;
- and
- wherein the neutral osmol agent is selected from the group consisting of glycerol, sorbitol, mannitol, xylitol, erythritol, and trehalose.
Dependencies are inferred from the claim text.