Back to results
US 11,957,690 B2Granted
Chromogenic beta-lactamase substrate
AssigneeBrown University
InventorsAnita Shukla, Dahlia Alkekhia, Shashank Shukla, Hannah Safford
Life of this patent
Estimating the term…
Abstract
The invention provides a chromogenic β-lactam molecule that retains its diagnostic color change response when modified for conjugation to another molecule.
Claims3
A diagnostic agent that changes color in response to presence of beta lactamases, wherein the diagnostic agent consists of the following formula:
- wherein the maleimide moiety in the structure above facilitates conjugation to a hydrogel forming polymer;
- further wherein the polymer is not an oligosaccharide;
- and wherein the diagnostic color change response is from clear to yellow when the B-lactam ring is hydrolyzed, expelling the 4-nitrobenzenethiol leaving group.
Dependencies are inferred from the claim text.