Methods for inducing an immune response
AssigneeMoonshot Pharma LLC
InventorAngela Christiano
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Abstract
Provided herein, inter alia, are compositions and methods for generating a immune response in an individual and/or inducing the expression of neoantigens on the surface of abnormal (such as proliferative) cells via promotion of premature termination codon (PTC) read-through and inhibition of nonsense-mediated decay (NMD) of messenger RNAs (mRNAs) bearing PTCs.
Claims20
A method of treating cancer in an individual in need thereof comprising administering to the individual an effective amount of a composition comprising ataluren and a compound that inhibits one or more immune checkpoint molecules selected from CTLA4, PD-1, PD-L1, A2AR, B7-H3, B7-H4, and TIM3.
A method of generating an immune response against a neoantigen expressed on a cancer cell surface in an individual in need thereof comprising administering to the individual an effective amount of a composition comprising ataluren and a compound that inhibits one or more immune checkpoint molecules selected from CTLA4, PD-1, PD-L1, A2AR, B7-H3, B7-H4, and TIM3.
Dependencies are inferred from the claim text.