Pharmaceutical composition for preventing or treating alopecia areata acting as a functional antagonist for S1PR1 and S1PR4
AssigneeNextgen Bioscience Co., Ltd.
InventorsBong Yong Lee, Yang Hae Park, Eun Jeong Kim
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Abstract
The present invention relates to a pharmaceutical composition for preventing or treating alopecia areata acting as a functional antagonist for S1P receptor's subtypes S1PR1 and S1PR4, and more particularly, relates to a pharmaceutical composition containing as an active ingredient a sphingolipid compound acting as a functional antagonist for S1PR1 and S1PR4, does not cause cardiovascular side effects, and is effective in preventing or treating alopecia areata.
Claims10
A method for treating alopecia areata, comprising administering a compound represented by the following Formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof to a subject in need thereof:
- wherein,
- R1 is hydrogen;
- R2 is hydrogen or an acetyl group;
- X is a single bond, C2 alkylene, or C2 alkenylene;
- A is a 5-membered heteroarylene ring containing 3 N atoms;
- B is C2-11 straight- or branched-chain alkylene;
- C is a single bond;
- and
- D is selected from the group consisting of hydrogen, and C1-6 alkyl.
Dependencies are inferred from the claim text.