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US 11,957,660 B2Granted
Edaravone suspension for oral administration
AssigneeMitsubishi Tanabe Pharma Corporation
InventorsTetsuo Hayama, Tomohiro Takahashi, Tomoyuki Omura, Kouji Hayashi, Munetomo Matsuda, Tadashi Miyazawa
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Abstract
An edaravone suspension for human oral administration includes edaravone particles, a dispersant, and water.
Claims20
An edaravone suspension for human oral administration, comprising:
- water;
- a thickening agent comprising at least one of tragacanth powder and xanthan gum;
- edaravone particles comprising edaravone and dispersed in the water;
- and
- a dispersant dispersing the edaravone particles in the water such that the dispersant maintains the edaravone particles in a solid particle state in the water,
- wherein a blending amount of the edaravone particles is in a range of 0.2% (w/v) to 36% (w/v), and the edaravone suspension does not contain a preservative selected from the group consisting of methylparaben, ethylparaben, propylparaben, butylparaben, benzoic acid, sorbic acid, sodium benzoate, benzyl alcohol, phenylethanol and a combination thereof, and does not have a bacterial growth for at least 28 days according to the preservation efficacy test of Japanese Pharmacopeia.
3 more elements
An ALS therapeutic agent, comprising:
- a drug product comprising edaravone and a thickening agent comprising at least one of tragacanth powder and xanthan gum,
- wherein a dose of the drug product per one oral administration is in a range of 1 to 20 mL and contains the edaravone in a range of 50 to 210 mg, and the dose of the drug product per one oral administration does not contain a preservative selected from the group consisting of methylparaben, ethylparaben, propylparaben, butylparaben, benzoic acid, sorbic acid, sodium benzoate, benzyl alcohol, phenylethanol and a combination thereof, and does not have a bacterial growth for at least 28 days according to the preservation efficacy test of Japanese Pharmacopeia.
Dependencies are inferred from the claim text.