Transmucosal dephosphorylated psychoactive alkaloid composition and preparation thereof
AssigneePsilo Scientific Ltd.
InventorsRyan Moss, Benjamin Lightburn, Lisa Ranken
Life of this patent
Estimating the term…
Abstract
A transmucosal psychoactive alkaloid composition including a psychoactive alkaloid extract or synthetic psychoactive alkaloid. The alkaloids in the extract are predominantly dephosphorylated rather than phosphorylated. The transmucosal psychoactive alkaloid composition also includes a mucoadhesive polymer, a carrier, and optional further excipients. The non-ingestive composition may be taken orally through the mucosa. A process for obtaining an oral transmucosal psychoactive alkaloid composition includes dephosphorylating the alkaloid during extraction, purifying the extracted alkaloid and standardizing to a specific concentration by adding measured quantities of excipients.
Claims29
A transmucosal psychoactive alkaloid composition consisting of, by weight:
- 1-40% of a dephosphorylated psychoactive alkaloid extract comprising a psychoactive alkaloid that is psilocin, bufotenine, bufotenidine, norpsilocin, 4-hydroxytryptamine, N,N,N-trimethyl-4-hydroxytryptamine or any combination selected therefrom;
- 1-50% of mucoadhesive polymer;
- 10-65% of carrier;
- and
- 0-30.5% in total of one or more excipients other than the mucoadhesive polymer and the carrier.
A process for obtaining a transmucosal psychoactive alkaloid composition, the process comprising:
- mixing a dried powdered psychoactive alkaloid source with an acidified solvent to obtain a slurry, wherein:
- the dried powdered psychoactive alkaloid source comprises psilocin, bufotenine, bufotenidine, norpsilocin, 4-hydroxytryptamine, N,N,N-trimethyl-4-hydroxytryptamine, psilocybin, baeocystin, norbaeocystin, aeruginascin or any combination selected therefrom;
- and
- the acidified solvent has a pH of 3.5 or lower and is a mixture of an acid and a solvent that is a C1-C4 primary aliphatic alcohol, a C3-C4 ketone, water or any combination selected therefrom;
- filtering the slurry to obtain a psychoactive alkaloid liquid;
- adjusting the pH of the psychoactive alkaloid liquid to a pH ranging from 3.5-4.5;
- evaporating the solvent from the psychoactive alkaloid liquid to obtain a dephosphorylated psychoactive alkaloid extract comprising a psychoactive alkaloid that is psilocin, bufotenine, bufotenidine, norpsilocin, 4-hydroxytryptamine, N,N,N-trimethyl-4-hydroxytryptamine or any combination selected therefrom;
- and
- mixing the dephosphorylated psychoactive alkaloid extract with a mucoadhesive polymer and one or more other excipients including a carrier.
Dependencies are inferred from the claim text.