Methods of treating hearing loss
AssigneeThe Regents of the University of California
InventorElliott Sherr
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Abstract
Provided are methods of treating various forms of hearing loss caused by aberrant calcium fluxes in auditory cells. The methods encompass the administration of agents which prevent abnormal calcium fluxes, stabilize SERCA2b activity, or prevent ER UPR apoptotic responses. The methods include therapeutic treatments of subjects suffering from hearing loss as well as preventative treatments which protect auditory cells from cell death, for example as caused by exposure to loud noise.
Claims10
A method of treating, in an animal, a hearing loss condition caused by unfolded protein response (UPR)-mediated cell death of auditory cells, comprising
- the administration of a pharmaceutically effective amount of an agent which inhibits protein kinase-like ER kinase (PERK)-mediated apoptosis of auditory cells;
- wherein the hearing loss condition is selected from the group consisting of noise-induced hearing loss, genetic or inherited hearing loss, and hearing loss experienced as a result of exposure to an ototoxic agent, wherein the ototoxic agent is cisplatin.
Dependencies are inferred from the claim text.