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US 11,953,499 B2Granted
Detection of molecule-nanoparticle interactions with ligand shells
AssigneeUniversity of South Carolina
InventorsMorgan Stefik, Zachary Marsh
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Abstract
A quartz crystal microbalance coated with functionalized nanoparticles used to detect molecule-nanoparticle interactions to assist with characterization of difficult to predict molecule-nanoparticle interactions for novel ligand chemistries and, particularly, mixed ligand nanoparticles exhibiting different ligand morphologies, in order to quantify nanoparticle-molecule interactions independently from more complex solvation requirements.
Claims4
A method to quantify mixed ligand shell molecule-nanoparticle interaction comprising:
- measuring vapor phase uptake of molecules into a solid nanoparticle film, deposited on a crystal, via nuclear magnetic resonance, wherein the nanoparticle film comprises mixed ligand nanoparticles with constant size and variable composition;
- wherein the method is independent of solvation criteria, wherein measurements are conducted with the solid nanoparticle film surrounded by a solvent;
- and
- wherein ligand stripping is employed, removing at least one ligand from the solid nanoparticle film prior to measuring vapor phase uptake.
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Dependencies are inferred from the claim text.