Multi-chip packaging of integrated circuits and flow cells for nanopore sequencing
AssigneeRoche Sequencing Solutions, Inc.
InventorsYuri Mitnick, Xu Ouyang, Janusz B. Wojtowicz
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Abstract
A nanopore-based sequencing system includes a plurality of nanopore-based sequencing chips. Each of the nanopore-based sequencing chips comprises a plurality of nanopore sensors. The system comprises at least one flow cell coupled to at least one of the plurality of nanopore-based sequencing chips, wherein the flow cell coupled to the at least one of the plurality of nanopore-based sequencing chips comprises one or more fluidic flow channels that allow a fluid external to the system to flow on top of the nanopore-based sequencing chip and out of the system. The system further comprises a printed circuit board electrically connected to the plurality of nanopore-based sequencing chips.
Claims13
A nanopore-based sequencing system or instrument, comprising:
- a plurality of nanopore-based sequencing chips, each of the nanopore-based sequencing chips comprising a plurality of nanopore sensors;
- a flow cell disposed over the plurality of nanopore-based sequencing chips, wherein the flow cell disposed over the plurality of nanopore-based sequencing chips comprises one or more fluidic flow channels configured to allow a fluid to flow over the plurality of nanopore-based sequencing chip;
- a printed circuit board electrically connected to the plurality of nanopore-based sequencing chips;
- and
- a plurality of bond wires, and wherein the printed circuit board further comprises a plurality of metal connectors, and wherein the plurality of bond wires electrically connect at least one of the plurality of nanopore-based sequencing chips to at least some of the plurality of metal connectors, and wherein the plurality of bond wires arch upwards and do not touch one another.
A nanopore-based sequencing system or instrument, comprising:
- a plurality of nanopore-based sequencing chips, each of the nanopore-based sequencing chips comprising a plurality of nanopore sensors;
- a flow cell disposed over the plurality of nanopore-based sequencing chips, wherein the flow cell disposed over the plurality of nanopore-based sequencing chips comprises one or more fluidic flow channels configured to allow a fluid to flow over the plurality of nanopore-based sequencing chip;
- and
- a printed circuit board electrically connected to the plurality of nanopore-based sequencing chips;
- wherein the plurality of nanopore-based sequencing chips are embedded in the printed circuit board, and wherein the printed circuit board further comprises a plurality of metal connectors, and wherein at least one of the plurality of metal connectors has a portion that lies flat on a top surface of the printed circuit board and that lies flat on a top surface of one of the plurality of nanopore-based sequencing chips, and wherein the at least one of the plurality of metal connectors is electrically connected to the one of the plurality of nanopore-based sequencing chips.
A nanopore-based sequencing system or instrument, comprising:
- a plurality of nanopore-based sequencing chips, each of the nanopore-based sequencing chips comprising a plurality of nanopore sensors;
- a flow cell disposed over the plurality of nanopore-based sequencing chips, wherein the flow cell disposed over the plurality of nanopore-based sequencing chips comprises one or more fluidic flow channels configured to allow a fluid to flow over the plurality of nanopore-based sequencing chip;
- and
- a printed circuit board electrically connected to the plurality of nanopore-based sequencing chips;
- wherein the printed circuit board comprises a plurality of cavities, and wherein the at least one of the plurality of nanopore-based sequencing chips is positioned right-side up and below the printed circuit board such that the plurality of nanopore sensors of the nanopore-based sequencing chip are exposed by one of the plurality of cavities.
A nanopore-based sequencing system or instrument, comprising:
- a plurality of nanopore-based sequencing chips, each of the nanopore-based sequencing chips comprising a plurality of nanopore sensors;
- a plurality of flow cells disposed over the plurality of nanopore-based sequencing chips, wherein each flow cell is disposed over a separate nanopore-based sequencing chip, wherein the plurality of flow cells disposed over the plurality of nanopore-based sequencing chips each comprise one or more fluidic flow channels configured to allow a fluid to flow over the nanopore-based sequencing chip;
- and
- a printed circuit board electrically connected to the plurality of nanopore-based sequencing chips.
Dependencies are inferred from the claim text.