Method for reducing analyzer variability using a normalization target
AssigneeQuidel Corporation
InventorsDavid Dickson Booker, Jhobe Steadman
Life of this patent
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Abstract
Disclosed herein is a method for improving the precision of a test result from an instrument with an optical system that detects a signal. The method comprises including in the instrument a normalization target disposed directly or indirectly in the optical path of the optical system. Also disclosed are instruments comprising a normalization target, and systems comprising such an instrument and a test device that receives a sample suspected of containing an analyte.
Claims20
A method to improve precision of a test result from an instrument, comprising:
- providing an instrument comprising a normalization target embedded in or on the instrument, the normalization target having an assigned normalization value based on its detected signal relative to detected signal associated with a calibration value stored in instrument memory;
- scanning or imaging in a single scan:
- (i) a test cartridge inserted into the instrument to obtain a test signal;
- and
- (ii) the embedded normalization target to obtain a current normalization value;
- and
- optionally adjusting the test signal by a scaling factor based on the current normalization value to optionally obtain a scaled test result with improved precision relative to test signal.
A method to improve precision of a test result from an instrument, comprising:
- providing an instrument comprising a normalization target embedded in or on the instrument, the normalization target comprised of a rhodamine and having an assigned normalization value based on its detected signal relative to detected signal associated with a calibration value stored in instrument memory;
- scanning or imaging in a single scan:
- (i) a test cartridge inserted into the instrument to obtain a test signal;
- and
- (ii) the embedded normalization target to obtain a current normalization value;
- and
- optionally adjusting the test signal by a scaling factor based on the current normalization value to obtain a scaled test result with improved precision relative to test signal.
A system, comprising:
- an instrument with an optical field comprising an optics module or a digital camera positioned to interrogate a test device positionable in the optical field, and a normalization target embedded in or on the instrument directly or indirectly in the optical field, and
- an external calibrant having a calibration value stored in instrument memory.
Dependencies are inferred from the claim text.