Compositions and methods for creating nanoscale surface geometries on metals of an implantable device
AssigneeTech Met, Inc.
InventorsMichael Vidra, Daniel Jon Schutzer, Jordan Incerpi
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Abstract
Compositions and methods for etching a nanoscale geometry on a metal or metal alloy surface are disclosed. Such surfaces, when included on an implantable medical device, enhance healing after surgery. When included on a bone contacting medical implant, the nanoscale geometry may enhance osseointegration. When included on a tissue contacting device, the nanoscale geometry may enhance endothelial cell attachment, proliferation, and restoration of a healthy endothelial surface.
Claims19
A composition for etching a nanoscale geometry into a surface of a body implantable device formed of a metal or metal alloy, the composition comprising:
- 1.2N-3.0N hydrochloric acid (HCl), 2.0N-4.0N nitric acid (HNO3), 0.1N-0.3N phosphoric acid (H3PO4), 0.1N-0.3N hydrofluoric acid (HF), and
- component metals of the body implantable device, wherein the metal or metal alloy of the body implantable device comprises stainless steel, and the composition comprises 3.75 g/l-90 g/l of each of chromium (Cr), molybdenum (Mo), and nickel (Ni), and up to 225 g/l iron (Fe),
- wherein the body implantable device is a bone-contacting device and the nanoscale geometry enhances osseointegration when the bone-contacting device is implanted adjacent living bone, or
- wherein the body implantable device is a tissue-contacting device and the nanoscale geometry enhances endothelial attachment and proliferation when the tissue-contacting device is implanted adjacent tissue.
A composition for etching a nanoscale geometry into a surface of a body implantable device formed of a metal or metal alloy, the composition comprising:
- 0.5N-3.5N hydrofluoric acid (HF) and 0.1N-3.0N nitric acid (HNO3), and
- component metals of the body implantable device, device, wherein the metal or metal alloy of the body implantable device comprises a nickel-titanium alloy, and the composition comprises:
- 3.75 g/l-90 g/l of each of nickel (Ni) and titanium (Ti),
- wherein the body implantable device is a bone-contacting device and the nanoscale geometry enhances osseointegration when the bone-contacting device is implanted adjacent living bone, or
- wherein the body implantable device is a tissue-contacting device and the nanoscale geometry enhances endothelial attachment and proliferation when the tissue-contacting device is implanted adjacent tissue.
A composition for etching a nanoscale geometry into a surface of a body implantable device formed of a metal or metal alloy, the composition comprising:
- 0.5N-3.5N hydrofluoric acid (HF) and 0.1N-3.0N nitric acid (HNO3), and
- component metals of the body implantable device, wherein the metal or metal alloy of the body implantable device comprises a nickel-chromium-molybdenum alloy, and the composition comprises:
- 3.75 g/l-90 g/l of each of chromium (Cr), and molybdenum (Mo), and up to 225 g/l iron (Fe),
- wherein the body implantable device is a bone-contacting device and the nanoscale geometry enhances osseointegration when the bone-contacting device is implanted adjacent living bone, or
- wherein the body implantable device is a tissue-contacting device and the nanoscale geometry enhances endothelial attachment and proliferation when the tissue-contacting device is implanted adjacent tissue.
A composition for etching a nanoscale geometry into a surface of a body implantable device formed of zirconia, the composition consisting of:
- 0.5N-3.5N hydrofluoric acid (HF) and 0.1N-3.0N nitric acid (HNO3), and
- soluble zirconia (ZnO2) and up to 225 g/l iron (Fe),
- wherein the body implantable device is a bone-contacting device and the nanoscale geometry enhances osseointegration when the bone-contacting device is implanted adjacent living bone, or
- wherein the body implantable device is a tissue-contacting device and the nanoscale geometry enhances endothelial attachment and proliferation when the tissue-contacting device is implanted adjacent tissue.
Dependencies are inferred from the claim text.