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US 11,952,615 B2Granted
Nucleic acid control molecules from non-human organisms
AssigneeExact Sciences Corporation
InventorsHatim T. Allawi, Graham P. Lidgard, Brian Aizenstein, Melissa M. Gray
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Abstract
The present invention provides synthetic DNA strands that find use as process controls in DNA processing and nucleic acid testing methods. In particular, provided herein are synthetic methylated DNA strands of known composition for use as control molecules in DNA testing, e.g., of mutations and/or methylation of DNA isolated from non-fish samples, such as human samples.
Claims19
A kit for analyzing methylated DNA from a biological sample from a human, the kit comprising:
- a) synthetic methylated DNA comprising a zebrafish DNA nucleotide sequence;
- b) an oligonucleotide comprising a region complementary to said synthetic methylated DNA;
- c) an oligonucleotide comprising a region complementary to methylated DNA from a human;
- and
- d) a methylation-specific reagent system.
2 more elements
Dependencies are inferred from the claim text.