Microorganisms and methods for improved biological production of ethylene glycol
AssigneeLanzaTech, Inc.
InventorsZachary Robert Cowden, Ching Leang, Michael Koepke, Rasmus Overgaard Jensen, Alexander Paul Mueller
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Abstract
The disclosure provides genetically engineered microorganisms and methods for improved biological production of ethylene glycol and precursors of ethylene glycol. The microorganism of the disclosure produces ethylene glycol or a precursor of ethylene glycol through one or more of 5,10-methylenetetrahydrofolate, oxaloacetate, citrate, malate, and glycine. The disclosure further provides compositions comprising ethylene glycol or polymers of ethylene glycol such as polyethylene terephthalate.
Claims20
A genetically engineered C1-fixing microorganism capable of producing ethylene glycol or a precursor of ethylene glycol from a gaseous substrate comprising:
- a disruptive mutation in a gene encoding diol dehydratase.
Dependencies are inferred from the claim text.