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US 11,952,594 B2Granted
Pharmaceutical compositions comprising bacterial delivery vehicles and uses thereof
AssigneeEligo Bioscience
InventorsAntoine Decrulle, Xavier Duportet, Igor Stzepourginski
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Abstract
The present invention relates to the delivery of a payload by bacterial delivery vehicle, i.e. the encapsulation and the delivery of a single plasmid by different bacterial virus particles. More specifically, the present invention concerns a pharmaceutical composition comprising a payload packaged in at least two different bacterial delivery vehicles and a method of production thereof.
Claims15
A pharmaceutical composition comprising at least two different bacterial delivery vehicles into which the same payload is packaged, wherein the payload comprises:
- a nucleic acid sequence of interest under the control of a promoter;
- and
- at least two orthogonal bacterial virus packaging sites that allow packaging of said payload into said at least two different bacterial delivery vehicles,
- wherein the nucleic acid sequence of interest leads to cell death of targeted bacteria, encodes reporter genes, elicits an immune response, encodes proteins or enzymes modifying the metabolism of targeted bacteria or encodes proteins or enzymes modifying the environment of targeted bacteria.
1 more element
A payload, comprising:
- (i) a nucleic acid sequence of interest under the control of a promoter;
- and
- (ii) at least two orthogonal bacterial virus packaging sites that allow packaging of said payload into said at least two different bacterial delivery vehicles,
- wherein the nucleic acid sequence of interest leads to cell death of targeted bacteria, encodes reporter genes, elicits an immune response, encodes proteins or enzymes modifying the metabolism of targeted bacteria or encodes proteins or enzymes modifying the environment of targeted bacteria.
1 more element
Dependencies are inferred from the claim text.