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US 11,952,590 B2Granted
Stromal stem cells
AssigneeOrbsen Therapeutics Limited
InventorStephen J. Elliman
Life of this patent
Estimating the term…
Abstract
Stromal stem cells are prospectively isolated from human bone marrow then expanded into clonal populations and cultured and used, the isolation being on the basis of expression of a cell surface marker, wherein the cell surface marker binds an antibody and wherein said antibody cross reacts with a cell surface marker found on mouse stromal stem cells or rat stromal stem cells, and optionally also on a cell of at least one other mammalian species selected from mouse, rat, horse, rabbit and pig cells. Useful stromal stem cell populations are positive for SDC2.
Claims11
A composition comprising:
- (i) a population of mammalian stromal stem cells, wherein 30% or more of the cells are positive for SDC2;
- and (ii) a permeating cryopreservant, wherein the population of mammalian stromal stem cells exhibits at least 10-fold more colony forming units per 10{circumflex over ( )}5 cells plated compared with native pre-sorted mononuclear cells.
Dependencies are inferred from the claim text.