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US 11,952,575 B2Granted
Transaminase mutant and use thereof
AssigneeAsymchem Life Science (Tianjin) Co., Ltd
InventorsHao Hong, Gage James, Jiangping Lu, Xingfu Xu, Wenyan Yu, Xin Huang, Yulei Ma, Yibing Cheng
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Abstract
A transaminase mutant and use hereof, the amino acid sequence of the transaminase mutant is an amino acid sequence in which the amino acid sequence as represented by SEQ ID NO: 1 is mutated, the mutated amino acid position being one or more selected from among F89, K193, P243, V234, I262, Q280, V379, R416, A417 and C418. The enzymatic activity and/or stability of the transaminase mutant is improved.
Claims6
A transaminase mutant, wherein the amino acid sequence of the transaminase mutant is the mutated amino acid sequence of SEQ ID NO:
- 1, and wherein the mutated amino acid sequence comprises mutations at one or more of amino acids selected from a group consisting of P243E, F89Y/W, K193E, V234I, I262V, Q280K, V379L/M/T, R416A/C/H/Q/T/S, A417S and C418A/Q/S, wherein “/” stands for “or”, and wherein the mutations at one or more of amino acids must comprise V379.
Dependencies are inferred from the claim text.