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US 11,952,495 B1Granted
Fluorogenic pH-sensitive compounds and their methods of use
AssigneeLife Technologies Corporation
InventorsYi-Zhen Hu, Aimei Chen, Daniel Beacham, Chrisgen Vonnegut, Krishnamurthy Nacharaju
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Abstract
The present disclosure provides for compounds of Formula (I), its corresponding compounds of Formula (II) or salts thereof and their use as fluorogenic pH sensors.
Claims15
A compound chosen from a compound of Formula (I):
- its corresponding compound of Formula (II)
- wherein,
- O—X—Y is chosen from
- D is
- wherein
- R5, R6, R7 and R8 are each independently chosen from H and alkyl;
- and
- R9, R10, R11 and R12 are each independently chosen from H, alkyl, sulfo and sulfonyl;
- or
- R8 is taken together with R12 and the atoms to which they are attached to form an optionally substituted fused ring;
- or R9 is taken together with R5 and the atoms to which they are attached to form an optionally substituted fused ring;
- or R10 is taken together with R7 and the atoms to which they are attached to form an optionally substituted fused ring;
- or R11 is taken together with R6 and the atoms to which they are attached to form an optionally substituted fused ring.
10 more elements
Dependencies are inferred from the claim text.