Neutrophil-binding peptides
AssigneesYissum Research Development Company of the Hebrew University of Jerusalem, Hadasit Meidcal Research Services & Development Ltd.
InventorsZvika Granot, Zvi Gregorio Fridlender, Sandra Vols
Life of this patent
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Abstract
Disclosed are peptides that specifically bind to neutrophils and uses thereof for neutrophil-targeted delivery of drugs or diagnostic agents in medical conditions including cancer as well as infectious, inflammatory and autoimmune diseases or disorders.
Claims20
A peptide comprising an amino acid sequence selected from the group consisting of:
- (SEQ ID NO:
- 1)
- KFPDLDSRRLPHMSL;
- (SEQ ID NO:
- 2)
- LATTHMVFSPDH;
- (SEQ ID NO:
- 3)
- PSSNLESTPLSLL;
- (SEQ ID NO:
- 4)
- SSLMTTQLIATSI;
- (SEQ ID NO:
- 5)
- PELDSKPYFPPL;
- (SEQ ID NO:
- 6)
- ELVTASMPRPNN;
- (SEQ ID NO:
- 7)
- SLESSPMAQLPQ;
- (SEQ ID NO:
- 8)
- SELRSTPLLVPS;
- (SEQ ID NO:
- 10)
- STMTILGTGS;
- (SEQ ID NO:
- 11)
- TETSLRIVSTNP;
- (SEQ ID NO:
- 12)
- LSIVSGSALNHL;
- and
- (SEQ ID NO:
- 13)
- LTLVSERPMI.
A method of targeting an agent to a human neutrophil, the method comprising administering to a human subject a composition comprising a peptide comprising any one of SEQ ID NO:
- 1-8 attached directly or through a carrier or linker to an agent, thereby targeting said agent to a human neutrophil.
A method of targeting an agent to a murine neutrophil, the method comprising administering to a murine subject a composition comprising a peptide comprising any one of SEQ ID NO:
- 10-13 attached directly or through a carrier or linker to an agent, thereby targeting said agent to a murine neutrophil.
A peptide comprising the amino acid sequence LQIQSWSSP (SEQ ID NO:
- 9).
Dependencies are inferred from the claim text.