Recombinant monoclonal antibodies and corresponding antigens for colon and pancreatic cancers
AssigneePrecision Biologics, Inc.
InventorsJ. Andrew Bristol, Judith A. Kantor
Life of this patent
Estimating the term…
Abstract
The present invention provides for recombinant monoclonal antibodies that bind to human colorectal and pancreatic carcinoma-associated antigens, along with nucleic acid sequences encoding the antibody chains, and the amino acid sequences corresponding to the nucleic acids, and uses for these antibodies, nucleic acids and amino acids.
Claims22
An isolated nucleic acid molecule selected from the group consisting of at least one of the following:
- a nucleic acid molecule with the nucleic acids of SEQ ID NO:12, a nucleic acid molecule with the complementary sequence of SEQ ID NO:12, a nucleic acid molecule with the sequence of SEQ ID NO:13, and the complementary sequence of SEQ ID NO:13.
An isolated nucleic acid molecule that encodes an antibody variable region light chain comprising a complementarity determining region (CDR) 1 comprising the amino acid residues GASENIYGALN (SEQ ID NO:1) or QASENIYGALN (SEQ ID NO:4);
- a CDR2 comprising the amino acid residues GASNLAD (SEQ ID NO:2) or GASNLAT (SEQ ID NO:5);
- and a CDR3 comprising the amino acid residues QNVLSSPYT (SEQ ID NO:3) or QQVLSSPYT (SEQ ID NO:6).
An isolated nucleic acid molecule that encodes an antibody variable region heavy chain comprising a CDR1 comprising the amino acid residues GYTFTDYAMH (SEQ ID NO:7);
- a CDR2 comprising the amino acid residues LISTYSGDTKYNQNFKG (SEQ ID NO:8) or LISTYSGDTKYNQKFQG (SEQ ID NO:10) or LISTYSGDTKYSQKFQG (SEQ ID NO:30);
- and a CDR3 comprising the amino acid residues GDYSGSRYWFAY (SEQ ID NO:9) or GDYSGSRYWFAY (SEQ ID NO:11).
Dependencies are inferred from the claim text.