Methods for treating multiple myeloma

A method of treating relapsed or refractory multiple myeloma in a human subject in need thereof, comprising administering a therapeutically effective amount of a BCMAxCD3 bispecific antibody to the subject to treat the cancer,

• wherein the subject is relapsed or refractory to treatment with at least one prior anti-cancer treatment,
• wherein the BCMAxCD3 bispecific antibody comprises a BCMA binding domain comprising a heavy chain variable region (VH) having the amino acid sequence of SEQ ID NO:
• 10 and a light chain variable region (VL) having the amino acid sequence of SEQ ID NO:
• 11, and a CD3 binding domain comprising a VH having the amino acid sequence of SEQ ID NO:
• 20 and a VL having the amino acid sequence of SEQ ID NO:
• 21,
• wherein the BCMAxCD3 bispecific antibody is administered subcutaneously at a dose of about 1500 μg/kg weekly, and
• wherein the method is effective in treating the multiple myeloma.