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US 11,952,425 B2Granted
High affinity B7-H6 antibodies and antibody fragments
AssigneeTrustees of Dartmouth College
InventorsMargaret Ackerman, Casey Hua, Charles Sentman
Life of this patent
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Abstract
Provided herein, in some embodiments, are antibodies, antigen-binding antibody fragments, chimeric antigen receptors (CARs) and bispecific T cell engagers (BiTEs) that bind specifically to B7 homolog 6. Also provided herein are methods of using the same and cells comprising the same.
Claims21
An antibody or antigen-binding antibody fragment that binds specifically to B7 homolog 6 (B7-H6) which comprises either of the following:
- I. (a) a heavy chain variable region comprising, (i) a CDR1 of SEQ ID NO:
- 31, (ii) a CDR2 of SEQ ID NO:
- 32, and (iii) a CDR3 of SEQ ID NO:
- 33;
- and (b) a light chain variable region comprising, (i) a CDR1 of SEQ ID NO:
- 34, (ii) a CDR2 of SEQ ID NO:
- 35, and (iii) a CDR3 of SEQ ID NO:
- 36;
- or II. (a) a heavy chain variable region comprising, (i) a CDR1 of SEQ ID NO:
- 22, (ii) a CDR2 of SEQ ID NO:
- 23, and (iii) a CDR3 of SEQ ID NO:
- 24;
- and (b) a light chain variable region comprising, (i) a CDR1 of SEQ ID NO:
- 25, (ii) a CDR2 of SEQ ID NO:
- 26, and (iii) a CDR3 of SEQ ID NO:
- 27.
13 more elements
Dependencies are inferred from the claim text.