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US 11,952,424 B2Granted
Multivalent antibody
AssigneeMerus N.V.
InventorsCornelis Adriaan de Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
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AssigneeMerus N.V.
InventorsCornelis Adriaan de Kruif, Linda Johanna Aleida Hendriks, Ton Logtenberg
Estimating the term…
The invention relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains; and at least one additional binding domain, wherein the base antibody portion is connected by a linker to the at least one additional binding domain, wherein each binding domain of the base antibody portion and each of the at least one additional binding domains all have a common variable region, and wherein the linker comprises a hinge sequence or a sequence derived from a hinge sequence. The invention also relates to a multivalent antibody which comprises: a base antibody portion which comprises two binding domains; and at least one additional binding domain, wherein at least one additional binding domain comprises a CH1 region and is connected to the base antibody portion by said linker, linking a variable region of the base antibody portion and the CH1 region, and wherein the multivalent antibody binds to at least three different epitopes.
A multivalent antibody which comprises:
Dependencies are inferred from the claim text.