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US 11,952,421 B2Granted
Bispecific antibodies against CD3EPSILON and ROR1
AssigneeBristol-Myers Squibb Company
InventorsMinh Diem Vu, Klaus Strein, Oliver Ast, Tanja Fauti, Anne Freimoser-Grundschober, Ralf Hosse, Christian Klein, Ekkehard Moessner, Samuel Moser, Ramona Murr, Pablo Umana, Sabine Jung-Imhof, Stefan Klostermann, Michael Molhoj, Joerg Regula, Wolfgang Schaefer
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Abstract
The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use.
Claims6
A bispecific antibody which specifically binds human CD3ε comprising SEQ ID NO:
- 63 and an extracellular domain of human ROR1 comprising SEQ ID NO:
- 1, said bispecific antibody comprising:
- (a) heavy chain polypeptides of SEQ ID NO:
- 37 and SEQ ID NO:
- 38, and light chain polypeptides of SEQ ID NO:
- 39 and SEQ ID NO:
- 40;
- or
- (b) heavy chain polypeptides of SEQ ID NO:
- 37 and SEQ ID NO:
- 38, and light chain polypeptides of SEQ ID NO:
- 39 and SEQ ID NO:
- 41.
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Dependencies are inferred from the claim text.