Nucleic acids encoding anti-TREM-1 antibodies
AssigneeBristol-Myers Squibb Company
InventorsAchal Pashine, Michael L Gosselin, Aaron P. Yamniuk, Derek A. Holmes, Guodong Chen, Priyanka Apurva Madia, Richard Yu-Cheng Huang, Stephen Michael Carl
Life of this patent
Estimating the term…
Abstract
Provided herein are antibodies, or antigen-binding portions thereof, that specifically bind and inhibit TREM-1 signaling, wherein the antibodies do not bind to one or more FcγRs and do not induce the myeloid cells to produce inflammatory cytokines. Also provided are uses of such antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of autoimmune diseases.
Claims25
A nucleic acid encoding heavy and light chains of an antibody which specifically binds to TREM-1, the antibody comprising a heavy chain CDR1, CDR2, CDR3;
- a light chain CDR1, CDR2, CDR3;
- and an IgG1 heavy chain constant region,
- wherein the heavy chain CDR1, CDR2, and CDR3 comprises TYAMH (SEQ ID NO:
- 24), RIRTKSSNYATYYAASVKG (SEQ ID NO:
- 25), and DMGIRRQFAY (SEQ ID NO:
- 26), respectively;
- wherein the light chain CDR1, CDR2, and CDR3 comprises RASQSVDTFDYSFLH (SEQ ID NO:
- 27), RASNLES (SEQ ID NO:
- 28), and QQSNQDPYT (SEQ ID NO:
- 29), respectively;
- wherein the IgG1 heavy chain constant region comprises amino acid substitutions selected from:
- (i) L234A, L235E, and G237A, per EU numbering;
- (ii) K214R, L234A, L235E, G237A, D356E, and L358M, per EU numbering;
- (iii) K214R, L234A, L235E, G237A, A330S, P331S, D356E, and L358M, per EU numbering;
- (iv) K214R, C226S, C229S, and P238S, per EU numbering;
- or
- (v) S131C, K133R, G137E, G138S, Q196K, 1199T, N203D, K214R, C226S, C229S, and P238S, per EU numbering;
- and
- wherein the IgG1 heavy chain constant region optionally comprises one or more amino acid deletions.
A nucleic acid encoding heavy and light chains of an antibody which specifically binds to TREM-1, the antibody comprising a heavy chain and a light chain, wherein the heavy chain comprises SEQ ID NO:
- 52 or SEQ ID NO:
- 53, and wherein the light chain comprises SEQ ID NO:
- 54.
A nucleic acid encoding an antibody heavy chain, the nucleic acid comprising SEQ ID NO:
- 58 or SEQ ID NO:
- 59.
Dependencies are inferred from the claim text.