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US 11,952,416 B2Granted
Anti-annexin A1 antibodies
AssigneeThe Trustees of Columbia University in the City of New York
InventorYiping Han
Life of this patent
Estimating the term…
Abstract
Anti-annexin A1 antibodies are provided and methods of treating FAP and cancer using Anti-annexin A1 antibodies, antibody fragments or fusion proteins, including bispecific antibodies targeting two different annexin A1 epitopes, are also provided.
Claims12
An antibody which binds annexin A1, or an annexin A1-binding fragment thereof, or an annexin A1-binding fusion protein, comprising:
- a) a heavy chain comprising:
- CDR1 comprising the amino acid sequence in SEQ ID NO:2;
- CDR2 comprising the amino acid sequence in SEQ ID NO:4;
- CDR3 comprising the amino acid sequence in SEQ ID NO:6;
- and a light chain comprising:
- comprising the amino acid sequence in SEQ ID NO:8;
- CDR2 comprising the amino acid sequence SAS, SEQ ID NO:10;
- CDR3 comprising the amino acid sequence in SEQ ID NO:12;
- or
- b) a heavy chain comprising:
- CDR1 comprising the amino acid sequence in SEQ ID NO:14;
- CDR2 comprising the amino acid sequence in SEQ ID NO:16;
- CDR3 comprising the amino acid sequence in SEQ ID NO:18;
- and a light chain comprising:
- CDR1 comprising the amino acid sequence in SEQ ID NO:20;
- CDR2 comprising the amino acid sequence DTS, SEQ ID NO:22;
- CDR3 comprising the amino acid sequence in SEQ ID NO:24;
- or
- c) a heavy chain comprising:
- CDR1 comprising the amino acid sequence in SEQ ID NO:26;
- CDR2 comprising the amino acid sequence in SEQ ID NO:28;
- CDR3 comprising the amino acid sequence in SEQ ID NO:30;
- and a light chain comprising:
- CDR1 comprising the amino acid sequence in SEQ ID NO:32;
- CDR2 comprising the amino acid sequence GAT, SEQ ID NO:34;
- CDR3 comprising the amino acid sequence in SEQ ID NO:36.
23 more elements
An antibody which binds annexin A1 comprising the complementary-determining regions (CDRs), wherein each of the CDRs has an amino acid sequence as follows:
- CDR1 comprising the amino acid sequence in SEQ ID NO:
- 2;
- CDR2 comprising the amino acid sequence in SEQ ID NO:
- 4;
- CDR3 comprising the amino acid sequence in SEQ ID NO:
- 6;
- CDR4 comprising the amino acid sequence in SEQ ID NO:
- 8;
- CDR5 comprising the amino acid sequence SAS, SEQ ID NO:10;
- and CDR6 comprising the amino acid sequence in SEQ ID NO:
- 12.
8 more elements
Dependencies are inferred from the claim text.