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US 11,952,402 B2Granted
Fusion protein containing trail and IgG binding domain and the uses thereof
AssigneeWest China Hospital, Sichuan University
InventorsXiaofeng Lu, Hao Yang, Ze Tao, Jingqiu Cheng
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Abstract
A recombinant protein includes a TRAIL domain and an IgG binding domain IgBD. In the recombinant protein, IgBD can be fused at the N-terminus or C-terminus of the TRAIL domain. The anti-tumor effect of the recombinant protein after binding to endogenous or exogenous IgG is significantly stronger than that of TRAIL, and can be used in the treatment of cell proliferative diseases with high expression of death receptors.
Claims15
A nucleotide sequence, comprising:
- (1) a sequence segment encoding a function domain of TRAIL;
- and
- (2) a sequence segment encoding a IgG-binding domain;
- wherein the TRAIL is derived from monkey or human TRAIL the IgG-binding domain is from streptococcus protein G, and
- wherein the nucleotide sequence is shown as any one of SEQ ID NO:7, 8 or 15.
2 more elements
Dependencies are inferred from the claim text.