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US 11,952,397 B2Granted
Crystalline forms of a neuroactive steroid
AssigneeSage Therapeutics, Inc.
InventorsShanming Kuang, Tianrui Li
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Abstract
This invention relates to crystalline forms of anhydrous Compound (1) and pharmaceutical compositions thereof. Also disclosed herein are methods of making crystalline solid forms of Compound (1), and methods of using the crystalline forms of Compound (1) and pharmaceutical compositions thereof for modulating GABA activity (e.g., positive allosteric modulation of GABA activity) and treating CNS-related disorders.
Claims7
A crystalline form of Compound (1), wherein Compound (1) is represented by the following structural formula:
- wherein the crystalline form is crystalline anhydrous Compound (1), and wherein the crystalline form is characterized by one or more peaks corresponding to 2-theta values measured in degrees of 15.4±0.3, 15.6±0.3, 18.1±0.3, 18.8±0.3, and 22.6±0.3 in an X-ray powder diffraction pattern.
Dependencies are inferred from the claim text.