N-azaspirocycloalkane substituted N-heteroaryl compounds and compositions for inhibiting the activity of SHP2

A compound of formula:

• wherein:
• Y1 is N;
• Y2 is CR6;
• R1 is —XR1a;
• wherein
• R1a is selected from C6-10aryl, C3-8cycloalkyl, C3-8cycloalkenyl and a 5-9 member heteroaryl group containing from 1 to 4 heteroatoms or groups independently selected from N, C(O), O and S;
• wherein said aryl or heteroaryl of R1a is substituted with 1 to 5 R9 groups independently selected from halo, amino, hydroxy, N3, C1-4alkoxy, C1-4alkyl, dimethyl-amino, hydroxy-substituted—C1-4alkyl, halo-substituted-C1-4alkyl, amino-substituted-C1-4alkyl, —C(O)OR10, —C(O)NH2, and —NHC(O)R10;
• wherein R10 is selected from hydrogen, phenyl, and naphthyl;
• wherein said phenyl of R10 is unsubstituted or substituted with methoxy;
• X is selected from S(O)m, O, CR10aR10b, NR11;
• wherein m is selected from 0, 1 and 2;
• each R10a and R10b is independently selected from halo and C1-4alkyl;
• and R11 is selected from hydrogen and C1-4alkyl;
• and
• R6 is selected from hydrogen, halo, cyano, C1-4alkyl, C1-4alkoxy, amino-carbonyl, halo-substituted C1-4alkyl, halo-substituted C1-4alkoxy, hydroxy-substituted C1-4alkyl, amino-substituted C1-4alkyl, —S(O)1-2R6a, —C(S)R6a, —C(O)NR6aR6b, —C(NH)NR6aR6b and —NR6aC(O)R6b;
• wherein R6a and R6b are independently selected from hydrogen and C1-4alkyl;
• or a pharmaceutically acceptable salt thereof.