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US 11,952,383 B1Granted
Aza-podophyllotoxin analogues as potential anti-cancer agents
AssigneeKing Faisal University
InventorsChristophe Tratrat, Michelyne Haroun
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Abstract
The present subject matter involves novel tetracyclic aza-podophyllotoxin analogue compounds, a method of synthesizing said compounds, a pharmaceutical composition comprising said compounds and a suitable carrier, and a method of using the compounds. The tetracyclic aza-podophyllotoxin analogue compounds are useful as antitumor agents.
Claims12
A process for synthesizing a compound having the formula I:
- or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein
- represents a double bond,
- n is 1;
- W represents oxygen (O);
- X represents an oxygen;
- R1 represents:
- a hydrogen atom;
- R2, R3, R4, and R5, which may be the same or different, each represent:
- a hydrogen atom;
- and
- R6 is an aryl or a heteroaryl optionally substituted in one or more positions with one or more of —OCH3, —OH, CH3, —NCH3, —NH2, —NHCOCH3, —F, —Cl, and —Br, the process comprising the following general reaction scheme:
- wherein Ar is an aryl or a heteroaryl optionally substituted in one or more positions with one or more of —OCH3, —OH, CH3, —NCH3, —NH2, —NHCOCH3, —F, —Cl, and —Br;
- and
- wherein 2-aminobenzimidazole and tetronic acid are reacted with aldehydes.
11 more elements
Dependencies are inferred from the claim text.