Small molecule modulators of PAR2 and uses thereof
AssigneesArizona Board of Regents on Behalf of the University of Arizona, Board of Regents, The University of Texas System
InventorsScott A. Boitano, Josef Vagner, Theodore J. Price, Greg Dussor
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Abstract
This invention is in the field of medicinal pharmacology. In particular, the invention relates to a new class of small-molecules having a pyrazino-pyrimidine-dione (or related) structure which function as modulators (activators, inhibitors) of protease activated receptor type 2 (PAR2), and their use as therapeutics for the treatment of conditions involving PAR2 activity (e.g., asthma, chronic pain, cancer and/or vascular disorders).
Claims22
A composition comprising a compound having a structure encompassed within Formula I,
- wherein:
- R1 is selected from
- R2 is selected from hydrogen,
- R3 is selected from hydrogen
- R4 is selected from hydrogen,
- or a pharmaceutically acceptable salt, solvate, and/or prodrug thereof;
- and
- wherein the resulting compound activates or inhibits PAR2 biological activity.
A composition comprising a compound having a structure encompassed within Formula I
- wherein:
- R1 is selected from
- R2 is selected from
- R3 is selected from hydrogen,
- and
- R4 is selected from hydrogen,
- or a pharmaceutically acceptable salt, solvate, and/or prodrug thereof;
- and
- wherein the resulting compound activates or inhibits PAR2 biological activity.
Dependencies are inferred from the claim text.