Crystalline forms of Mnk inhibitors
AssigneeeFFECTOR Therapeutics, Inc.
InventorsSiegfried H. Reich, Paul A. Sprengeler, Stephen E. Webber, Alan X. Xiang, Justin T. Ernst, Bennett C. Borer, Samuel Sperry, Jo Ann Z. Wilson
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Abstract
The present invention provides crystalline solids of 6′-((6-aminopyrimidin-4-yl)amino)-8′-methyl-2′H-spiro[cyclohexane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione: The crystalline compounds of the present application are inhibitors of Mnk and finds utility in any number of therapeutic applications, including but not limited to treatment of inflammation and various cancers.
Claims6
A process of producing a compound having the structure,
- the process comprising;
- a) reacting compound (1),
- with cyclohexanone and sulfuric acid to produce compound (2),
- b) reacting compound (2) with compound (3),
- in the presence of Pd(OAc)2 and potassium carbonate to produce compound (4)
- c) reacting compound (4) with ethylenediamine and potassium hydroxide to produce compound (5)
A process of producing a crystalline solid of a compound having the structure:
- wherein the crystalline solid is characterized by an X-ray powder diffraction pattern comprising peaks, expressed in values of degrees 2θ, at about 8.07;
- about 10.81;
- about 14.68;
- and about 22.07±0.2, the process comprising
- a) creating a suspension of the compound in aqueous ethanol at 35° C. to 45° C.
- b) cooling the suspension to room temperature
- c) filtering the suspension to isolate a cake of crystalline solid
- d) washing the cake with aqueous ethanol, and
- e) drying the cake under vacuum to constant weight.
A solid pharmaceutical composition comprising a therapeutically effective amount of a crystalline solid of a compound having the structure:
- and a pharmaceutically acceptable particulate carrier, wherein the crystalline solid of the compound is characterized by an X-ray powder diffraction pattern comprising peaks, expressed in values of degrees 2θ, at about 8.07;
- about 10.81;
- about 14.68;
- and about 22.07±0.2.
Dependencies are inferred from the claim text.