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US 11,952,374 B2Granted
Bicyclic compounds
AssigneeAligos Therapeutics, Inc.
InventorsSandrine Vendeville, Pierre Jean-Marie Bernard Raboisson, David McGowan
Life of this patent
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Abstract
Provided herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, pharmaceutical compositions that include a compound described herein (including pharmaceutically acceptable salts of a compound described herein) and methods of synthesizing the same. Also provided herein are methods of treating diseases and/or conditions with a compound of Formula (I), or a pharmaceutically acceptable salt thereof.
Claims21
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure:
- wherein:
- n is 1;
- Z1 is —C(═O)—;
- R1 is selected from the group consisting of
- R2 and R3 are independently selected from the group consisting of hydrogen and an unsubstituted C1-4 alkyl;
- R4, R5, R6 and R7 are each hydrogen;
- R8 is selected from the group consisting of an optionally substituted monocyclic heteroaryl and —NR14AR14B;
- R9 is a substituted phenyl, a substituted monocyclic heteroaryl or a substituted fused-bicyclic heteroaryl, wherein the substituted phenyl, the substituted monocyclic heteroaryl or the substituted fused-bicyclic heteroaryl is substituted with one or more substituents selected from the group consisting of halogen, an unsubstituted C1-4 alkyl, an unsubstituted C1-4 haloalkyl, an unsubstituted C1-4 alkoxy, an optionally substituted monocyclic heteroaryl, an optionally substituted monocyclic heterocyclyl, amino, a mono-substituted amine, a di-substituted amine and —C(═O)NHR15;
- R14A is a monocyclic C3-6 cycloalkyl optionally substituted with one or two halogens, a monocyclic C3-6 cycloalkyl(C1-4 alkyl) optionally substituted with one or two halogens, an optionally substituted 4-6 member monocyclic heterocyclyl or an optionally substituted monocyclic 4- to 6-membered heterocyclyl(C1-4 alkyl);
- R14B is selected from the group consisting of an optionally substituted aryl and an optionally substituted aryl(C1-4 alkyl);
- and
- R15 is hydrogen, an unsubstituted C1-6 alkyl, an optionally substituted C2-6 alkenyl, an optionally substituted C1-6 alkynyl or an optionally substituted C3-6 monocyclic cycloalkyl.
9 more elements
Dependencies are inferred from the claim text.