Substituted 1,3,5-triazines as inhibitors for a rho family of GTP-ases

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• A is a 6-membered aromatic ring or a 6-membered heteroaromatic ring;
• wherein the 6-membered heteroaromatic ring contains 1 or 2 nitrogen heteroatoms;
• and
• wherein the 6-membered aromatic ring or the 6-membered heteroaromatic ring is optionally substituted with one substituent selected from the group consisting of halogen, C1-6 alkyl, C1-6 haloalkyl, NH2, NHC1-6 alkyl, N(C1-6 alkyl)2, OH, and O(C1-6 alkyl);
• A′ is a 6-membered aromatic ring or a 6-membered heteroaromatic ring;
• wherein the 6-membered heteroaromatic ring contains 1 or 2 nitrogen heteroatoms;
• and
• wherein the 6-membered aromatic ring or the 6-membered heteroaromatic ring is optionally substituted with one substituent selected from the group consisting of halogen, C1-6 alkyl, C1-6 haloalkyl, NH2, NHC1-6 alkyl, N(C1-6 alkyl)2, OH, and O(C1-6 alkyl);
• X1 is —CH2—, —NR2—, or —O—;
• X2 is —CH2—, —NR2—, or —O—;
• R1 is H or C1-6 alkyl;
• R2 is H, C1-6 alkyl, C(O)C1-6 alkyl, C(O)O(C1-6 alkyl), or O(C1-6 alkyl);
• and
• Y is N;
• with the provisos that:
• (1) X1 and X2 are not simultaneously —NR2—;
• (2) X1 and X2 are not simultaneously —NR2— and —O—;
• and
• (3) X1 and X2 are not simultaneously —O—.