Dibenzothiophene compounds
AssigneeSaint Louis University
InventorsJohn T. Petroff, II, Ryan D. McCulla
Life of this patent
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Abstract
The present invention generally relates to various dibenzothiophene compounds, processes for preparing these compounds, and uses of these compounds. The present invention also relates to cell imaging agents comprising one or more of the dibenzothiophene compounds and processes for imaging a cell using the compounds. The present invention further relates to methods of producing ground state atomic oxygen.
Claims19
A compound of Formula (I), or salt thereof:
- wherein
- R1 is hydrogen, hydroxy, substituted or unsubstituted hydrocarbyl, or substituted or unsubstituted amino;
- R2 is:
- R3 is hydrogen, substituted or unsubstituted alkyl;
- or substituted or unsubstituted alkenyl;
- R4 is unsubstituted C1-C3 alkylene or substituted or unsubstituted alkenylene;
- and
- n is 1 or 2.
A compound having a structure selected from the group consisting of:
- and salts thereof.
A compound having a structure of formula (II-b):
- wherein
- R1 is hydrogen, hydroxy, substituted or unsubstituted hydrocarbyl, or substituted or unsubstituted amino;
- R2 is:
- R3 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
- R4 is substituted or unsubstituted alkylene, substituted or unsubstituted alkenylene, or substituted or unsubstituted alkynylene;
- and
- n is 1 or 2.
A process of visualizing a cell comprising applying an imaging agent comprising a compound of Formula (I), or salt thereof to the cell, applying light to stimulate the emission of a luminescent signal from the imaging agent, and detecting the signal, wherein the compound of Formula (I), or salt thereof has a structure corresponding to:
- wherein
- R1 is hydrogen, hydroxy, substituted or unsubstituted hydrocarbyl, or substituted or unsubstituted amino;
- R2 is:
- R3 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkynyl;
- R4 is substituted or unsubstituted alkylene, substituted or unsubstituted alkenylene, or substituted or unsubstituted alkynylene;
- and
- n is 1 or 2.
Dependencies are inferred from the claim text.