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US 11,952,353 B2Granted
STAT3 transcription factor inhibitors and methods of using the same
AssigneeThe Regents of the University of Colorado
InventorsPhilip Reigan, Donald S. Backos, Christopher J. Matheson, Steffanie L. Furtek, Craig T. Jordan, Maria L. Amaya
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Abstract
Compounds that inhibit the activity of Signal transducer and activator of transcription 3 (STAT3), or pharmaceutically acceptable salts or prodrugs thereof, and methods of using these compounds to treat cancer and other diseases.
Claims16
A compound of Formula (I):
- a prodrug thereof, or a pharmaceutically acceptable salt thereof, wherein:
- R1 is nitro, CN, SO3H, —C(═O)—OR1S, —(C═O)—N(R1S)2, or N(R1S)2;
- each R1S independently is H or C1-6 alkyl;
- R2 is halogen;
- R3 is H or C1-6 alkyl;
- R4 is halogen;
- R5 is 5- to 12-membered heteroaryl optionally substituted with one or more R5S;
- each R5S independently is halogen, C1-6 alkyl, —OR5SS, —N(R5SS)2, —(C1-6 alkyl)-OR5SS, —(C1-6 alkyl)-N(R5SS)2, —C(═O)—R5SS, or —C(═O)—OR5SS;
- each R5SS independently is H or C1-6 alkyl;
- R6 is OR6S or —C(═O)—OR6S;
- and
- R6S is H or —C(═O)—C1-6 alkyl.
9 more elements
A compound being selected from:
- prodrugs thereof, and pharmaceutically acceptable salts thereof.
A compound being selected from:
- prodrugs thereof, and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.